Cardiovascular disease is the leading cause of death in the United States and globally. The improving cardiac function and treatment of chronic bradycardia (Heart Rate ≤ 60 beats per minute) remain an essential unsolved issue. With no regulatory-approved this type of drug for treatment, a pacemaker is used surgically placed into a patient's heart. With the limitation of pacemakers, some patients may face high risk. Notably, in some situations, such as in Space, when the element of gravity is replaced with weightlessness, a human heart shrinks, and the heart rate and cardiac output are lower in Space than on Earth observed in astronauts.
CARDIX Therapeutics is developing a new patent drug to improve cardiac function by increasing heart rate and cardiac output. The patent drug provides an alternative option to a pacemaker for treating chronic bradycardia. With a non-invasive methodology and non-electromagnetic interferences, it is promising to be suitable for astronauts/spacemen to protect or ameliorate their cardiac function in Space.